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Drug Availability and Pharmacokinetics


Amount of Bioavailable drug from a dosage plan
Bioequivalent amounts of two bio-inequivalent products
Plasma concentration of unbound drug (free drug)
Apparent volume of distribution
Total amount of drug content
Elimination rate constant & Elimination half-life
Creatinine Clearance and Dosage Calculation
- Ideal Body Weight
- Creatinine clearance rate
- Adjusting Creatinine clearance rate
- Loading dose & Maintenance dose based on Ideal Body Weight
















To calculate the amount of Bioavailable drug from a dosage plan

Total drug content in the dosage form:mg
Bioavailability factor (F):
Amount of Bioavailable drug =
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Bioequivalent amounts of two bio-inequivalent products

Drug content of the solid dosage form:mg
Bioavailability Factor of the drug in solid dosage form:
Drug content of the liquid dosage form:mg/mL
Bioavailability Factor of the drug in liquid dosage form:
Dose of liquid dosage form equivalent to solid dosage form =
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Plasma concentration of unbound drug (free drug)

α value of the drug:
Total plasma concentration of the drug (ng/mL):
Concentration of unbound drug in plasma (ng/mL):
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Apparent volume of distribution

Total amount of drug in the body:mg
Drug's plasma concentration:mg/L
Apparent volume of distribution
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Total amount of drug content

Drug's plasma concentration:mg/L
Apparent volume of distribution (L):
(or)
Apparent volume of distribution (in % of body weight):
Body weight (kg):
Total amount of drug content (mg)
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Elimination rate constant & Elimination half-life

Elimination rate constant:
Elimination half-life:
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Ideal Body Weight

Height (inches):
Sex : Male Female
Body Weight in : kg lb
Result =
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Creatinine clearance rate

Age (years):
Body weight (kg):
Sex : Male Female
Serum creatinine (mg/dL):
Calculate by : Jelliffe equation Gault equation
Creatinine clearance rate:
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Adjusting Creatinine clearance rate

Creatinine Clearance rate:mL/min.
Body Surface Area of the patient: m2 (or)
Body Weight (kg):
Height (cm):
Adjusted Creatinine clearance =
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Loading dose & Maintenance dose based on Ideal Body Weight

Height of the patient (inches):
Body weight (kg):
Age (years):
Sex : Male Female
Serum creatinine (mg/dL):
Desired loading dose (mg/kg):
Desired maintenance dose (mg/kg):
Patient condition :
Normal Renally impaired
Loading Dose =
Maintenance Dose =
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